TIsigner Expression Optimization
A nucleotide sequence based method for optimizing protein expression.
Overview
A nucleotide sequence based method for optimizing protein expression through accessibility of translation initiation sites modelled using the mRNA base-unpairing across the Boltzmann ensemble.
Run TIsigner Expression Optimization on Neurosnap
The TIsigner Expression Optimization online webserver allows anybody with a Neurosnap account to run and access TIsigner Expression Optimization, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong Terms of Use and Privacy Policy.
Features
- Expression optimization through lowering Opening Energy.
- Can optimize full-length sequences or the coding initiation region.
- Includes fine-tuning options for target expression score, species of expression, and other advanced settings.
Statistics
Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.
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API Request
Access TIsigner Expression Optimization using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.
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Citations
Please cite the original work when using TIsigner Expression Optimization in publications or research outputs.
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Bhandari, Bikash et al. "Analysis of 11,430 recombinant protein production experiments reveals that protein yield is tunable by synonymous codon changes of translation initiation sites", https://journals.plos.org/, 05 October 2021, https://doi.org/10.1371/journal.pcbi.1009461. |
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Neurosnap Inc. (2022). Neurosnap: An online platform for computational biology and chemistry. Available at: https://neurosnap.ai/ |